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What are the odds of getting breast cancer while carrying the brca gene

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What are the Odds of Getting Breast Cancer while Carrying the BRCA Gene?

In this brief review, we will explore the positive aspects and benefits of the article titled "What are the odds of getting breast cancer while carrying the BRCA gene?" This informative piece aims to provide a clear understanding of the likelihood of developing breast cancer for individuals carrying the BRCA gene mutation. The content is tailored for a US audience and is written in a simple and easy-to-understand style.

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    • The article provides a thorough explanation of the BRCA gene mutation and its association with breast cancer.
    • It details the odds and risk factors for developing breast cancer among individuals carrying the BRCA gene mutation.
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About 50 out of 100 women with a BRCA1 or BRCA2 gene mutation will get breast cancer by the time they turn 70 years old, compared to only 7 out of 100 women in the general United States population.

Can you carry the BRCA gene and not get cancer?

But some mutations in the BRCA1 and BRCA2 genes prevent them from working properly, so that if you inherit one of these mutations, you are more likely to get breast, ovarian, and other cancers. However, not everyone who inherits a BRCA1 or BRCA2 mutation will get breast or ovarian cancer.

Should you get a mastectomy if you have the BRCA gene?

Women with BRCA1 and BRCA2 mutations are more likely to get breast and ovarian cancer than other women. The most effective option for preventing breast and ovarian cancer in women with BRCA mutations is surgery to remove the breasts (mastectomy) and ovaries and fallopian tubes (salpingo-oophorectomy).

What are the odds of getting breast cancer with the gene?

About 5% to 10% of breast and 10% to 15% of ovarian cancers are hereditary. Hereditary cancer means cancer runs in your family, and could be caused by a change in certain genes that you inherited from your mother or father.

What type of breast cancer is most common in BRCA?

In view of histological types, approximately 75% of BRCA1 pathogenic variant breast cancers are invasive ductal carcinomas, and 10% are atypical medullary cancers. In BRCA2 pathogenic variant breast cancer, lobular or ductal with lobular types are more frequent (in up to 10% of cases) [25].

What percent of breast cancers are BRCA positive?

The authors estimate that only 7–10% of unselected women with breast cancer will test positive for a BRCA1 or BRCA2 mutation, whereas up to 25% of women with TN breast cancer unselected for family history will test positive [27].

Can you be BRCA positive with no family history?

There will be a subgroup of BRCA1 or 2‐positive patients with ovarian cancer without a family history of cancer, and these patients would have been missed if using family history of cancer and/or age at onset as selection criteria for testing.

Frequently Asked Questions

What percentage of people with BRCA1 get breast cancer?

Breast cancer: About 13% of women in the general population will develop breast cancer sometime during their lives (1). By contrast, 55%–72% of women who inherit a harmful BRCA1 variant and 45%–69% of women who inherit a harmful BRCA2 variant will develop breast cancer by 70–80 years of age (2–4).

What type of breast cancer is associated with BRCA1?

In view of histological types, approximately 75% of BRCA1 pathogenic variant breast cancers are invasive ductal carcinomas, and 10% are atypical medullary cancers. In BRCA2 pathogenic variant breast cancer, lobular or ductal with lobular types are more frequent (in up to 10% of cases) [25].

Can you have BRCA1 and not get cancer?

But some mutations in the BRCA1 and BRCA2 genes prevent them from working properly, so that if you inherit one of these mutations, you are more likely to get breast, ovarian, and other cancers. However, not everyone who inherits a BRCA1 or BRCA2 mutation will get breast or ovarian cancer.

What is the life expectancy of someone with the BRCA gene?

About 12 percent of the women had a mutation in either BRCA1 or BRCA2 that raised cancer risk. A person's cancer risk can vary a lot depending on which mutation they have. Most of the women lived 10 years; 73 percent of the women with BRCA mutations lived 10 years and 70 percent of women without the mutations did.

What is the mortality rate for the BRCA gene?

Results. Of the 3,345 patients enrolled onto the study, 233 (7.0%) carried a BRCA1 mutation. The 10-year survival rate for mutation carriers was 80.9% (95% CI, 75.4% to 86.4%); for noncarriers, it was 82.2% (95% CI, 80.5% to 83.7%).

What happens if you test positive for BRCA gene?

A positive test result indicates that a person has inherited a known harmful variant in BRCA1 or BRCA2 (these are typically called “pathogenic” or “likely pathogenic” variants on laboratory test reports) and has an increased risk of developing certain cancers.

FAQ

Who is at higher risk for the BRCA gene?
If either your mother or your father has a BRCA1 or BRCA2 gene mutation, you have a 50% chance of having the same gene mutation. Some groups are at a higher risk for a BRCA gene mutation than others, including women with Ashkenazi Jewish heritage.
What triggers BRCA1?
In the nucleus of many types of normal cells, the BRCA1 protein interacts with several other proteins to mend breaks in DNA. These breaks can be caused by natural and medical radiation or other environmental exposures, and they also occur when chromosomes exchange genetic material in preparation for cell division.
How do you inherit BRCA1?
Genes are passed from parent to child (inherited) when a sperm and egg join to start a pregnancy (conception). A woman, or person assigned female at birth, who inherits a BRCA1 or BRCA2 variant has: a high risk of breast and ovarian cancer. a 1 in 2 (50%) chance of passing the variant to each of their children.
What is one of the most significant predictors for BRCA1 mutations?
You and your family members are more likely to have a BRCA1 or BRCA2 mutation if your family has a strong history of breast or ovarian cancer. Family members who inherit BRCA1 and BRCA2 mutations usually share the same mutation.
Does BRCA gene come from mother or father?
A harmful variant in BRCA1 or BRCA2 can be inherited from either parent. Each child of a parent who carries any mutation in one of these genes has a 50% chance (or 1 in 2 chance) of inheriting the mutation. Inherited mutations—also called germline mutations or variants—are present from birth in all cells in the body.
Does a mutation in the BRCA1 gene cause breast cancer?
The genes most commonly affected in hereditary breast and ovarian cancer are the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes. About 3% of breast cancers (about 7,500 women per year) and 10% of ovarian cancers (about 2,000 women per year) result from inherited mutations in the BRCA1 and BRCA2 genes.

What are the odds of getting breast cancer while carrying the brca gene

What is the average age for breast cancer BRCA1? The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.
Is mastectomy recommended for BRCA1? Most women with a BRCA1 or BRCA2 gene mutation will develop breast cancer at some point. Having a prophylactic mastectomy before the cancer develops might add many years to their lives. But not all women with BRCA1 or BRCA2 mutations develop breast cancer. For some women the surgery might not have been helpful.
What are the odds of getting breast cancer with the BRCA gene? About 50 out of 100 women with a BRCA1 or BRCA2 gene mutation will get breast cancer by the time they turn 70 years old, compared to only 7 out of 100 women in the general United States population.
What percentage of breast cancer is related to BRCA1? The genes most commonly affected in hereditary breast and ovarian cancer are the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes. About 3% of breast cancers (about 7,500 women per year) and 10% of ovarian cancers (about 2,000 women per year) result from inherited mutations in the BRCA1 and BRCA2 genes.
What is the survival rate for BRCA1 breast cancer? Copson and colleagues reported that patients with a BRCA1 or BRCA2 mutation had a similar prognosis as patients without these mutations: in 2733 women included in the analysis, overall survival at 2 years was 97·0% (95% CI 94·5–98·4) for BRCA mutation carriers versus 96·6% (95·8–97·3) for non-carriers (hazard ratio [HR
Does BRCA1 increase risk of cancer? How much do BRCA mutations increase the risk of breast cancer? The risk of breast cancer for the average American woman is about 12 percent in her lifetime. Having a BRCA mutation greatly increases the risk. The estimated risk of breast cancer in women with a BRCA mutation is 45 to 85 percent by age 70.
  • Can my daughter have the BRCA gene if I don t?
    • A harmful variant in BRCA1 or BRCA2 can be inherited from either parent. Each child of a parent who carries any mutation in one of these genes has a 50% chance (or 1 in 2 chance) of inheriting the mutation. Inherited mutations—also called germline mutations or variants—are present from birth in all cells in the body.
  • What is the probability that their daughter has inherited the mutant BRCA gene?
    • If either your mother or your father has a BRCA1 or BRCA2 gene mutation, you have a 50% chance of having the same gene mutation. Some groups are at a higher risk for a BRCA gene mutation than others, including women with Ashkenazi Jewish heritage.
  • Is BRCA gene inherited from mother or father?
    • You can inherit mutations in BRCA1, BRCA2, and other genes from your mother or your father, so be sure to include information from both sides of your family when collecting your family health history.
  • What are the odds of having a BRCA mutation?
    • It is high. Having a BRCA mutation means you have a likelihood of 45% to 85% for developing breast cancer in your lifetime, along with a 10% to 46% chance of ovarian cancer. The probability of breast cancer among the general population is about 12%.
  • At what age should you get tested for the BRCA gene?
    • Professional consensus among genetic organizations has always been to discourage testing of minors (those younger than 18 years of age) for adult onset conditions, such as hereditary breast and ovarian cancer.